雷公藤多甙对兔眼缝线固定式人工晶体表面纤维蛋白膜形成的影响

Effects of tripterygium wilfordii polyglco sidium on the fibrinous membrane formation of transscleral fixation posterior chamber intraocular lense implantation in rabbits

目的：光镜和电镜下动脉观察雷公藤多甙对兔眼缝线固定式后房性人工晶体表面纤维蛋白膜形成的影响。方法：青紫蓝兔１８只，分为缝线固定式人工晶体植入组及雷公藤多甙治疗组。术后１ｄ、７ｄ、１４ｄ摘除人工晶体，作光镜和扫描电镜检查，采用ＳＡＳ软件包，对统计资料作秩和检验。结果：术后１ｄ、７ｄ和１４ｄ雷公藤多甙治疗组人工晶体表面纤维蛋白厚膜、薄膜和定位孔膜低于术后未治疗组（Ｐ＜０．０１）。结论：雷公藤多甙治疗能显著降低人工晶体表面的纤维蛋白膜形成。

Objective:To examine the pathological changes and morphological features of the fibrinous membrane formation on implanted transscleral fixation posterior chamber intraocular lensee (PC IOLs), and to study the effects of tripterygium wilfordii polyglyco sidium (TWP) on the fibrinous memberane of IOL in rabbitsMethods:Eighteen adult pigmented rabbits wee equally divided into two groups: (1)Rabbits with lens intracapsular extraction and transscleral fixation PC IOL; (2)Rabbits received TWP therapy after transscleral fixation PC IOL IOLs were extracted on days 1、7 and 14 after IOL implantation, and the pathological changes of IOLs were observed with light microscopy and scanning electron microscopy Statistic data were analyzed by rank sum test of SAS soft wereResults:It was found that the fibrinous memberane formation on IOL on lst, 7th and 14th postoperative days was significantly lower in TWP treated group than that in untreated transscleral fixation PC IOL implantation group, Conclusion:The current study offers that TWP is effective in reducing postoperative fibrinous memberane formation on IOL, and it may be closely related to the antiinflammatory and immunosuppressiue effects of TWP