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β-七叶皂甙钠治疗大鼠出血性脑水肿的MRI动态研究 被引量:1

A dynamic study on MRI of β-aescinum natrium on hemorrhage brain edema in rats
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摘要 目的研究β-七叶皂甙钠对大鼠出血性脑水肿的治疗作用。方法大鼠苍白球注射胶原酶造成脑出血模型,应用磁共振显像(MRI)观察治疗组和对照组各项指标的动态变化。结果治疗组大鼠的血肿及水肿吸收率明显高于对照组(P<0.05),各时间点水肿区的T2、FLAIR的信号强度比均明显低于对照组(P<0.05),信号强度比相对变化率明显高于对照组(P<0.05)。结论β-七叶皂甙钠对大鼠出血性脑水肿有明显的治疗作用。 Objective To study the therapeutic effect of β-aescinum natrium on hemorrhagic brain edema in rats. Methods The model of intracerebral hemorrhage( ICH) was established by infusing collagenase into right globus pallidus. The MRI was performed to compare the dynamic changes about various data of hemorrhagic brain edema of therapeutic group treated with β-aeseinum natrium and control group. Results In the β-aescinum natrium therapeutic group, the absorption rate of hematoma and edema were significantly higher than in the control group(P(0. 05). The FLAIR and T2 signal intensity ratio of edema area in the therapeutic group were obviously lower than of the control group at every point of time(P〈0. 05). The relative variance ratio of signal intensity ratio is significantly higher than in the control group (P〈0.05). Conclusions β-aescihum natrium has a significant therapeutic effect on hemorrhagic brain edema.
出处 《卒中与神经疾病》 2009年第4期240-242,247,共4页 Stroke and Nervous Diseases
关键词 脑水肿 脑出血β-七叶皂甙钠 磁共振显像 大鼠 动物模型 Erain edema Cerebral hemorrhage β-aescinum natrium MRI Rat Animal model
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