3%高渗盐水治疗重型颅脑损伤患者颅内高压的疗效分析

Study on Efficiency of Treatment of Elevated Intracranial Pressure of Severe Head Injury Patients with 3% Hypertonic Saline

目的:评价3%高渗盐水(HS)治疗重型颅脑损伤患者颅内高压的有效性和安全性。方法:回顾性分析了37例重型颅脑损伤患者的临床资料。结果:3%HS治疗组患者ICP降低更为显著,起效时间更快,持续时间更长。HS组患者MAP和CPP升高多于甘露醇组。治疗后,HS患者低钠血症发生率明显低于对照组。结论:3%HS可以考虑作为治疗重型颅脑损伤患者颅内高压的一线药物。

Objective： To investigate the efficiency and safety of treatment of elevated intracranial pressure（ICP） of severe head injury patients with 3% hypertonic saline（HS）.Methods： Clinical data of 37 severe head injury patients were analyzed retrospectively.Results： ICP of the patients treated via 3% HS decreased more obviously,which happened more quickly and lasted longer.The elevation of mean arterial pressure and cerebral perfusion pressure of the patients in HS group was higher than that in mannitol group,while fewer hyponatrimia happened in HS group.Conclusion： 3% HS should be considered to be the first-line osmotic drugs for elevated intracranial pressure of the severe head injury patients.