吸入糖皮质激素治疗稳定期COPD疗效研究

The Therapeutic Effects of Inhaling Glucocorticoid to Cure Stable COPD Patients

目的：观察吸入糖皮质激素对稳定期重度慢性阻塞性肺疾病（COPD）的疗效。方法：采用随机分组方法对本院2006～2007年门诊患者中筛选出符合入选标准的59例稳定期重度COPD患者进行随机分组,分别给予布地奈德/福莫特罗干粉吸入剂（治疗组）和福莫特罗干粉吸入剂（对照组）治疗半年,评估肺功能、呼吸困难程度、生活质量及慢性阻塞性肺疾病急性发作（AECOPD）等。疗效分析采用t检验或χ2检验。结果：59例患者均完成半年随访。结果显示：治疗组第1秒用力呼气、呼吸困难评分、6 min步行距离和生活质量评分等指标均较对照组明显改善。且急性加重患者的门诊和住院人次较对照组少（P〈0.05）。结论：吸入糖皮质激素治疗稳定期重度COPD有效。

Objective： To observe curative effect of inhaling glucocorticoid for serious COPD cases in stabilization period.Method： Fifty-nine cases of serious COPD outpatients in stabilization period were divided randomly to two groups in 2006～2007.Glucocorticoid were given for half year.The dyspneic respiration grade,6 min walking distance,quality of life grades and the 1st second forced expiration were evaluated.Results： All 59 cases are visited within half year period.The analysis conclusion of the Curative Group show：Compared with control group,the dyspneic respiration grade,6 min walking distance,quality of life grades and the 1st second forced expiration was improved obviously in the Curative Group（P〈0.05）.The number of outpatient clinic and hospitalization patients with acute exacerbation also decreased（P〈0.05）.Conclusion： Glucocorticoid can relieve COPD patient＇s clinical symptom in stable phrase,improve activity endurance,the quality of life and the lung function,and reduce the number of acute outbreak.