心踝血管指数与冠状动脉狭窄程度的关系

Correlation Between Cardio-Ankle Vascular Index and Coronary Artery Disease

目的探讨心踝血管指数对冠心病的预测价值。方法对497例冠状动脉造影患者行心踝血管指数测量、病史采集及常规化验检查。根据病变累及冠状动脉支数分为冠状动脉正常组(178例)、单支病变组(102例)、双支病变组(104例)和三支病变组(113例)。冠状动脉病变的严重程度用病变的血管支数及Gensini积分表示。比较各组患者冠心病危险因素以及心踝血管指数的差异,采用Logistic回归分析比较危险因素在冠心病发病中的作用。结果冠心病组患者的性别构成、年龄、高血压、糖尿病、血脂异常和吸烟率等显著高于冠状动脉正常组(P<0.05)。单支病变组、双支病变组和三支病变组心踝血管指数均显著高于冠状动脉正常组(P<0.05)。冠状动脉造影Gensini积分与心踝血管指数成正相关(r=0.763,P<0.01)。Logistic回归分析发现,年龄、高血压、糖尿病、血脂异常、吸烟以及心踝血管指数升高与冠心病的发生显著相关(P<0.05)。结论与年龄、高血压、糖尿病、血脂异常和吸烟一样,心踝血管指数增高也是冠心病发病的危险因素。心踝血管指数是冠心病冠状动脉狭窄严重程度的独立预测因子。

Aim To investigate the prognostic value of cardio-ankle vascular index （CAVI） in the occurrence of coronary heart disease （CHD）. Methods 497 patients treated with coronary angiography were studied. All patients underwent cardio-ankle vascular index （ CAVI ） and serum factors evaluation in addition to history collection. The severity of coronary artery stenosis was evaluated by the number of diseased arteries and Gensini score. The risk factors of coronary heart disease and CAVI were compared between each group. The predicting role of these variables, especially CAVI, to the occurrence of CHD was analysed with Logistic regression. Results There were significant differences in sex composition, age, hypertension, diabetics, hyperlipidemia and cigarette smoking between the CHD group and the non- CHD group （P 〈 0.05 ）. The CAVI were significantly higher in patients with coronary artery disease than in the normal subjects （P〈0.05）. There was a positive linear trend between CAVI and Gensini＇s score （r=0. 763, P〈0.01 ）. Multiple logistic analysis indicated that age, hypertension, diabetics, hyperlipidemia, cigarette smoking and CAVI were significantly correlated to the occurence of CHD （ P 〈 0.05 ）. Conclusion Just like age, hypertension,diabetics, hyperlipidemia and cigarette smoking, CAVI were also independent risk factors of CHD. CAVI was an unattached predictor of the severity of coronary artery stenosis.