甘精胰岛素、阿卡波糖与盐酸贝那普利联合治疗2型糖尿病早期肾病的临床观察

The Clinical Observation of Combinative Therapy of Early-Stage DN in T2DM with Insulin Glargine,Acarbose and Benazepril

目的:观察甘精胰岛素、阿卡波糖与盐酸贝那普利联合治疗2型糖尿病早期肾病的临床疗效。方法:将62例2型糖尿病合并糖尿病肾病III期患者用甘精胰岛素作为基础量使空腹血糖达标,三餐时联合阿卡波糖口服控制餐后血糖,辅以盐酸贝那普利治疗,观察治疗前后血糖、血压及尿白蛋白/肌酐的变化。结果:经甘精胰岛素、阿卡波糖治疗后空腹和餐后2 h血糖明显下降,联合盐酸贝那普利治疗可改善胰岛素抵抗,并使UAER明显下降。结论:甘精胰岛素作为基础量、联合阿卡波糖控制血糖,辅以盐酸贝那普利口服是治疗2型糖尿病合并早期糖尿病肾病的方法之一,疗效肯定,无低血糖发生。

Objective： To observe the clinical efficacy of insulin glargine, acarbose and benazepril in the combined treatment of early--stage diabetic nephropathy （DN） in type 2 diabetes mellitus （T2DM）. Methods： Using insulin glargine to treat 62 stage--Ⅲ diabetic nephropathy（DN） in type 2 diabetes mellitus patients as basic method in order to reduce the fasting blood--glucose. Using acarhose, combined with benazepril, to control the postprandial blood sugar When patients having dinner, to observe the dynamic changes of blood sugar, blood pressure and urinary albumin excretion rate（UAER） before and after treatment. Results： After the treatment with insulin glargine and acarbose, the 2h fasting blood--glucose and postprandial blood sugar dramatic decline. Combined with benazepril will im- prove the insulin sensitivity,reduce UAER. Conclusion： Using insulin glargine as basic method,combined with acarbose to control blood sugar, combined with benazepril taking orally, to treat stage--Ⅲ diabetic nephropathy（DN） in type 2 diabetes mellitus patients is effective,no hypoglycemia happened.