摘要
目的:观察采用疏血通注射液联合ACEI/ARB治疗早期糖尿病肾病(DN)的疗效。方法:将78例2型DN患者随机分为对照组(ACEI/ARB)和治疗组(ACEI/ARB+疏血通注射液),疗程4周。比较两组治疗前和治疗后尿微量白蛋白(mAlb),Scr、BUN等指标的变化。结果:(1)治疗后治疗组和对照组尿白蛋白均显著下降(P<0.01,P<0.05),治疗组比对照组下降更为明显(P<0.05)。(2)治疗后两组血浆白蛋白均增加(P<0.01),治疗组与对照组治疗后比较无明显差异(P>0.05)。(3)治疗后两组Scr、BUN、TC、TG和血钾均无明显变化。结论:联合应用疏血通注射液能有效减少早期DN患者的蛋白尿,改善肾功能。
Objective: To study the clinical effects of Shuxuetong and ACEI/ARB on early diabetic nephropathy (DN). Methods: 78 patients of type 2 Diabetic nephropathy were randomly divided into treatment group(ACEI/ARB+ Shuxuetong)and control group (ACEI/ARB). SCr,mAlb and BUN figures were compared between two groups before treatment and four weeks after treatment. Results: MAlb had been decreased significantly in both groups(P〈0.01 ,P 〈0. 05),and more significantly in treated group than in control group (P〈70. 05). Plasma albumin increased signifi- cantly in both groups(P〈0.01). But no significantly increase of plasma albumin bad been found in treatment group during the follow-up(P〉0.05). There were no significantly difference in SCr, BUN, TC, TG and serum kalium between two groups. Conclusion: Shuxuetong and ACEI/ARB can ameliorate proteinuria and improve renal function of the patients with early DN.
出处
《华西医学》
CAS
2009年第7期1748-1750,共3页
West China Medical Journal
关键词
疏血通注射液
早期糖尿病肾病
suxuetong injection
early diabetic nephropathy