O型孕妇血型抗体效价与新生儿溶血发病率的关系分析

Analysis of the Relationship between the Valence of IgG Antibody In Pregnant Women with Blood Type O and the Rate of Hemolytic Disease in the Newborn

目的:研究O型RhD阳性孕妇(其丈夫为非O型)血清IgG抗-A(抗-B)抗体效价与新生儿溶血病(HDN)的关系。方法:应用微柱凝胶技术对382例O型RhD阳性孕妇进行了免疫性IgG抗A(B)抗体效价检测及对其新生儿进行HDN(①新生儿ABO、Rh系统定型;②新生儿直抗实验;③游离IgG测定;④放散实验)的检测。结果:382例O型RhD阳性孕妇中IgG抗-A(B)效价<64者330例(占总数86.39%),抗体效价≥64者13.61%。其中发生HDN5例,抗-A 3例,抗-B 12例,总发生率1.31%。结论:夫妇血型不合应及时检测孕妇IgG抗体,随着孕妇体内IgG抗体效价的增高,新生儿ABO溶血病的发病率也随之升高。孕妇产前应定时进行IgG抗体检测,了解效价与新生儿溶血病发病率之问的关系,对于预防新生儿溶血病极为有效。

Objective： To investigate the relationship between the IgG antibody titer in serum of p regnant women with blood type O and the rate of Hemolytic disease in the newborn. Methods： IgG antibody titer in serum of p regnant woman with blood type O was detected by anti-human-globulin test in micro-column gel immunoassay. And four tests were performed with microcolumn Gel immunoassay （（1）Newborn ABO Rh system typed; （2）Direct antiglobin test;（3）Free lgGdetermination;（4）Elution test）. Results： Among 382 pregnant women with blood type O, IgG anti-A（B） antibody titers of 330（86.93%） pregnant women were〈64 and IgG anti-A（B） antibody titers of 52 pregnant women ≥64 （13.61%）. And the rate of hemolytic disease in the Newborn is 1.31% , respectively anti-A were 3, anti-B were 2. Conclusion： The rate of HDN is increased by the higher IgG antibody titer in serum of p regnant women. Detecting the valence of blood type antibody IgG in serum of pregnant women is helpful to diagnose hemolytic disease of the newborn and to instruct interventions to lower incidence of the disease.