氟芬那酸丁酯致突变实验

Mutational Test of Butylflufenamate

用氟芬那丁酯酸对４种鼠伤寒沙门氏菌营养缺陷型（ＴＡ）进行了回复突变试验和培养中国仓鼠肺细胞（ＣＨＬ）的染色体畸变试验．结果在加代谢活化系统（Ｓ９）或不加的条件下，氟芬那酸丁酯（剂量为０５～５０００μｇ·皿－１）对４种ＴＡ菌的回复突变菌落数无明显影响；对培养ＣＨＬ的５０％细胞抑制浓度为４０μｇ·ｍＬ－１，浓度为４～４０μｇ·ｍＬ－１的氟芬那酸丁酯对ＣＨＬ染色体无致畸变作用．提示本品无致突变作用．

To examine mutational effects of Butylflufenamate(Buf.)on retrieve of histidinerequiring mutants of Salmonella typhimurium(TA)and on chromosomal teratogenity of Chinese hamster lung cells (CHL)in culture.The results show that Buf. at the dosage of 05～5 000μg/plate has no retrieving effects on four TA strains, whether to add metablic activiting systems(S9)or not;and Buf. with IC50 value of 40μg/mL, at the dosage of 4～40μg/mL, has no chromosal teratogenity on CHL.These date show that Buf. has no mutagenicity.