迭代目标转换因子分析法测定多组分复方药物制剂的研究

Study on Iterative Target Transformation Factor Analysis Usde in Compound Preparations

采用迭代目标转换因子分析法同时测定复方冬眠灵片两组分的含量．用此法对复方冬眠灵片的两组分盐酸异丙嗪和盐酸氯丙嗪进行了测量及计算，获得满意结果．氯丙嗪平均回收率为１０１４％，ＲＳＤ为０４％（ｎ＝６）；异丙嗪平均回收率为１００４％，ＲＳＤ为１８％（ｎ＝６）．而用普通目标转换因子分析法测定，氯丙秦平均回收率为１０３１％，ＲＳＤ为４９％（ｎ＝６），异丙嗪平均回收率为９５４％，ＲＳＤ为２２％（ｎ＝６）．由此可看出迭代目标转换因子分析法较普通目标转换因子分析法具有明显的优势．

In this paper,we determined simultaneously two components on Dongmianling tablets with the iterative target transformation factor analysis and got satisfactory results.The mean recoveries of chlorpromazine hydrochloride and promethazine hydrochloride were 1014% and 1004%,respectively.The RSD were 04%and 18%(n=6),respectively.But with the ordinary target transformation factor analysis, the mean recoveries of chlorpromazine hydrochloride and promethazine hydrochloride were 1031%and 954%,respectively.The RSD were 49%and 22%,respectively. From this comparison,we knew the results of iterative target transformation factor analysis were better than those of the target transformation factor analysis.