摘要
目的:对苯妥英血药浓度进行分析。方法:对1989年11月至1996年11月间应用高效液相色谱法监测苯妥英血药浓度的数据进行统计。结果:在监测的15888份样本中,血药浓度低于10μg·ml-1占80.89%,高于20μg·ml-1的占4.77%,在有效血药浓度10~20μg·ml-1范围内仅占14.34%。结论:监测苯妥英血药浓度具有临床意义。
Aim: To determin the concentration of nitrendipine in plasma, Methods:GC method with an electron capture detector and splitless injection and SE54 quartz capillary column(0.32 mm×25m) were used.The sample was alkalized and extracted with methylbenzene.Nifedipine was used as internal standard.Results:The linear range was from 5~80 ng·ml-1(r=0.998 7).The recoveries of nitrendipine in plasma were 101.5%~103.4%,RSD<6%. Conclusion: This method is suitable for determination in serum.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1998年第8期348-349,共2页
Chinese Journal of Hospital Pharmacy
关键词
高效液相色谱
苯妥英
血药浓度
nitrendipine,gas chromatography,capillary column,electron capture detector,splitless injection