摘要
考察了盐酸川芎嗪肺靶向微球的微粉学性质、热解稳定性、载药量和体外释药模式。结果表明，微球为类白色圆球状粉末，平均算术粒径为１２．６５μｍ，５～２４．９μｍ，粒径范围的微球数占总数的８７．５％，平均堆密度为０．５９ｇ／ｍｌ，休止角为６８．６３°，临界相对湿度为５６％，热解活化能为８１．６ｋＪ／ｍｏｌ，反应级数为１。用ＵＶ法测得微球载药量为１７．０％，微球体外释药符合一级动力学规律。
The micropowder property, stability to thermal decomposition, drug content and drug releasing pattern in vitro of lung targeting microspheres of ligustrazine hydrochloride were investigated. The microspheres looked like whitish spherical powder, and the arithmetic mean diameter of the microsphers was 12.65 μm, with the amount in the range from 5 to 24.9 μm being 87.5% of the total. The mean bulk density was 0.59 g/ml, and the angle of repose 68.63°. The critical relative humidity was 56%. The activation energy of thermal decomposition was 81.6 kJ/mol with the reaction order of one. The drug content in microspheres was detemined ultravioletspectrophotometrically to be 17.0%; the drug release in vitro could be described by first order kinetics. The diameter range of microspheres met the requirements of lung targeting preparations.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1998年第8期354-359,共6页
Chinese Journal of Pharmaceuticals
基金
卫生部科学基金
关键词
盐酸川芎嗪
肺靶向微球
微粉学性质
热解活化能
ligustrazine hydrochloride, lung targeting microspheres, activation energy of thermal decompostion, second order derivative method
