生长抑素八肽治疗肝硬化食管胃底静脉曲张破裂出血的疗效

The effects of SRIF-8 on the hemorrhage of the rupture of the varicoesophagus and fundus ventricular varicosity

用垂体后叶素（ＶＰ）为对照，观察了生长抑素八肽（ＳＲＩＦ－８）治疗肝硬化食管胃底静脉曲张破裂出血的临床疗效及胃酸分泌和血浆胰高糖素（ＧＧ）的影响及其副作用。结果表明，ＳＲＩＦ－８的止血率和止血速度均明显优于ＶＰ，它可抑制肝硬化患者的基础胃酸（ＢＡＯ）分泌（Ｐ＜０．０１）可降低血浆ＧＧ（Ｐ＜０．０１）。

With the vasopressin(VP) as contral,we observed the clinical effects of somatotropin release Inhibitory Factor-9 Peptide(SRIF-8) on the hemorrhage of the repture of varicoesophagus and fundus ventricular varicosity.At the same time,we observed and compared their influence on the secretion of gasric acid and the levels of plasmatic Glucagon(GG).The results show that the hemostatic rate and velocity of SRIF-8 is better than that of VP.SRIF-8 may also inhibit the secretion of the BAO and decrease the level of plasmatic GG in patients with liver cirrhosis.