广州市40～65岁中老年人膳食大豆异黄酮摄人与血脂关系的横断面研究

Relationship between dietary soy isoflavones and blood lipid levels in 40-65 year-olds in Guangzhou

目的研究广州市中老年人大豆异黄酮摄入与血脂的关系。方法用食物频数问卷分析395名40—65岁广州市居民每日大豆异黄酮及其他食物和营养素的摄入量，抽取空腹静脉血测定血脂。结果134名男性和261名女性的大豆异黄酮摄入分别为11．95（0～61．96）mg／d和14．90（0—82．5Z）mg／d。按照大豆异黄酮摄人量将研究对象等分为低、中、高三组，在校正了总能量摄入和脂肪供能比后，三组间TC、LDL—C差异有统计学意义（P值分别为0．002、0．008），并存在剂量效应关系（趋势分析P值分别为〈0．001、0．012）；高摄入组与低摄入组相比，TC、LDL—C分别下降7．06％、10．13％。在进一步校正年龄、BMI和腰臀比后，上述结果无明显改变。结论膳食大豆异黄酮摄入与血浆TC、LDL—C负相关。

Objective To study the relationship between dietary soy isoflavones and blood lipids among residents of 40-65 years old, in Guangzhou. Methods Dietary soy isoflavones and other nutrients intakes were assessed with quantitative food frequency questionnaire （FFQ）. Total cholesterol（TC）, triglycerides （TG）, HDL cholesterol （HDL-C） and LDL cholesterol （LDL-C） in plasma were measured with colorimetry. Results Ranges of dietary soy isoflavones intake among 134 males and 261 females were from 0 mg/day to 61.96 mg/day and 0 mg/day to 82.52 mg/day, with means of 11.95 mg/day, 14.90 mg/day, respectively. After adjusted for total energy intake and fat percent energy, differences of TC, LDL-C in total population and TC in women were statistically significant between groups （P value was 0.002, 0.008, 0.004, respectively） and dose-effect relationships （P value was 〈0.001,0.012, 0.001, respectively） were observed between dietary soy isoflavones intake and the upper mentioned three indices. Compared with the low-intake group, these three indices lowered 7.06%, 10.13% and 7.48%, respectively in high-intake group. Critical significance of LDL-C was observed both in women and men between groups. Further controlled for age, BMI and WHR, no obvious change of the results was observed. Conclusion Moderate intakes of soy isoflavone as part of a regular diet seemed to be associated with favorable blood lipid levels.