苯海拉明霜联合甲硝唑霜综合治疗激素依赖性皮炎的疗效

Clinical efficacy of benadryl cream and metronidazle cream in treatment of topical corticosteroid dependent dermatitis

目的探讨用1％苯海拉明霜联合3％甲硝唑霜综合治疗激素依赖性皮炎的疗效和安全性。方法采用随机单盲方法，将90例激素依赖性皮炎患者分为3组：A组用1％苯海拉明霜＋3％甲硝唑霜综合疗法，B组用氯雷他定＋喜疗妥进行治疗，C组用激素递减法治疗，疗程均8周，在治疗的2、4、8周进行随访，并在治疗的第4、8周判断疗效。结果治疗8周后，A、B、C组的有效率分别为86．20％，73．33％，66．67％，3组疗效差异有统计学意义（P〈0．05），A组疗效明显高于B、C两组。3组治疗方法均无明显不良反应。结论1%苯海拉明霜十3％甲硝唑霜综合疗法是对激素依赖性皮炎有较显著疗效的方法。

Objective To assess the clinical efficacy and safety of 1% benadryl and 3 % metronidazle cream in the treatment of topical corticosteroid dependent dermatitis. Methods The study was conducted in a single-blind way. The 86 patients were divided into 3 groups： 1 % benadryl and 3 %metronidazle cream （group A）, loratadine （group B） and gluco-corticoids （group C）. All preparations were applied twice daily for 8 weeks. Study visits took place at baseline and weeks 2, 4 and 8. Results The clinical response rate in the groups A, B and C was 86. 20%, 73. 33%, and 66.67 %, respectively; the clinical response rate in group A was significantly higher than that in groups B and C （P〈0.05）. Conclusions 1% benadryl and 3% metronidazle cream are effective and safe in the treatment of topical torticosteroid dependent dermatitis.