摘要
目的:研究代谢综合征(MS)痰瘀互结证与胰岛素、C-反应蛋白(CRP)、肿瘤坏死因子(TNF-α)、胰岛素抵抗指数(HOMA-IR)、血脂等指标之间的关系,以探讨痰瘀互结证在代谢综合征辨证施治中的重要性,为中医辨证代谢综合征寻找客观依据。方法:共收集代谢综合征患者54例,根据辨证分为痰瘀互结型(25例)和非痰瘀互结型(29例)两组,测定两组患者的胰岛素、CRP、TNF-α、血脂等,分析上述指标与MS痰瘀互结辨证之间的关系。结果:两组血清胰岛素、CRP、TNF-α均高于对照组,差异有统计学意义(P<0.05或P<0.01)。代谢综合征患者两组比较,痰瘀互结组的空腹胰岛素(FIns)、CRP、HOMA-IR均高于非痰瘀互结型,差异有统计学意义(P<0.05或P<0.01)。结论:代谢综合征痰瘀互结证与FIns、HOMA-IR、CRP、TNF-α、TG之间有直接相关关系。
Objective: To study the relationship between the levels of serum insulin, C-reactive protein (CRP), Tumor Necrosis Factor (TNF- α ), insulin resistance index, blood fat, and phlegm-stagnation stasis syndrome of metabolic syndrome(MS), so as to discuss the significance of phlegm-stagnation stasis syndrome in treatment based on syndrome differentiation of MS, in order to find the objective evidence of differentiation of symptoms and signs of TCM of MS. Methods: In this study, 54 cases with MS were divided into groups of phlegm-stagnation stasis syndrome and non- phlegm-stagnation stasis syndrome according to the clinical symptoms, tongue demonstration and pulse tracings. There were 25 cases in phlegm-stagnation stasis group, 29 cases in non- phlegm-stagnation stasis group. The levels of serum insulin, CRP, TNF- α, blood fat were checked, the insulin resistance index was calculated. Results: The levels of serum insulin, CRP, TNF- α of the two groups of metabolic syndrome were significantly higher than those of the healthy persons ( P〈0.05 or P〈0.01 ) . The levels of fasting insulin , CRP, insulin resistance index, systolic blood pressure of the phlegm-stagnation stasis group are significantly higher than that of the nonphlegm-stagnation stasis group ( P〈0.05 or P〈0.01 ) . Conclusion : This study found that there were high levels of serum insulin, CRP, TNF- α in the patients with MS. Phlegm-stagnation stasis syndrome was significant in the differentiation of symptoms and signs of TCM in MS. There was direct relationship between phlegm-stagnation stasis syndrome in MS and fasting insulin, insulin resistance index, CRP, TNF- α, TG.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2009年第8期1076-1078,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
深圳市科技计划资助项目(No.200404122)