脉搏波传导速度与冠状动脉病变和心血管事件的关系

Study the relationship between pulse wave velocity and coronary atherosclerosis cardiovascular events

目的:分析脉搏波传导速度(PWV)与冠状动脉病变和心血管事件的关系。方法:入选2005年10月至2007年9月在我院体检中心进行体检的否认既往心血管病史的人群,共入选319例,男性215例,女性104例,年龄(48.7±14.2)岁。根据脉搏波传导速度:分为脉搏波传导速度增快组(≥1 400 cm/s,1 480±79 cm/s)共95例,脉搏波传导速度正常组(<1 400 cm/s,1 030±350 cm/s)共224例。在6～18个月后进行电话随访。结果:脉搏波传导速度增快组行冠状动脉CTA检查,20例有不同程度的冠状动脉硬化和斑块(20/95,21.1%),正常组只有6例(6/224,0.27%),2组比较差异有统计学意义(P<0.05)。脉搏波传导速度增快组的颈动脉内-中膜厚度(0.23±0.08)cm高于正常组(0.14±0.05)cm,血压(152±23)mm Hg(1 mm Hg=0.133 KPa)高于正常组(114±26)mm Hg,2组比较差异有统计学意义(P<0.05)。脉搏波传导速度增快组的甘油三脂、总胆固醇、空腹血糖和正常组比较有升高趋势,但没有统计学意义(P>0.05)。电话随访6～18个月的心血管事件:脉搏波传导速度增快组发生心绞痛12例、入院治疗8例,正常组没有,比较差异有统计学意义(P<0.05)。结论:脉搏波传导速度增快的动脉硬化人群发生冠状动脉病变的风险增加,心血管事件的发生率增加。

Objective： To study the relation between pulse wave velocity and coronary atherosclerosis, cardiovascular events. Method：309 cases with physical examination were analyzed with computer software from 2006 to 2007,215 males and 104 females, （48.7 ± 14.2） yrs. All cases did not have cardiovascular disease. There were divided into two groups, pulse wave velocity increased group（PWV） （ ≥ 1 400 cm/s, 1 480 ± 79） cm/s, pulse wave velocity normal group （PWV） （ 〈 1 400 cm/s, 1 030 ± 350） cm/s. All cases were visited by phone from 6-18 month. Result： PWV ≥ 1 400 cm/s group was higher than the normal group in coronary arteries disease （21.1% vs 0.27 % ）, there were significant difference（ P 〈 0.05）. PWV≥ 1 400 cm/s group was higher than the normal group in carotid arteries thickness （0.23 ± 0.08）cm vs （0.14 ± 0.05） cm and blood pressure（152 ± 23） mm Hg vs （114 ± 26） mm Hg）. There were significant difference （P 〈 0.05）. With the rise of the P WV, total triglycerides （TG）, total cholesterol （TC）, blood glucose showed increasing trends, but there are nut significant difference（ P 〉 0.05 ）. There was higher rate of cardiovascular events in PWV≥ 1 400 cm/s group than normal group. PWV≥ 1 400 cm/s group is higher than normal group in Angina pectoris and in hospital. Conclusion： With the rise of the PWV, coronary atherosclerosis, cardiovascular events increase.