血清β-淀粉样蛋白含量检测对老年性痴呆的临床意义

The clinical significance of content determination of serum β-amyloid in Alzheimer's disease

目的:探讨血清β-淀粉样蛋白(Aβ)含量在老年性痴呆(AD)诊断中的价值。方法:采用平衡饱和竞争放射免疫分析法检测30例AD组(分为轻、中、重三组)及30例智能正常老年对照组血清Aβ含量,所有数据均经SPSS11.0软件进行统计学处理。结果:AD组与智能正常老年对照组血清Aβ含量分别为(1.36±0.60)μg/L和(0.72±0.26)μg/L,AD组明显升高,与对照组比较,差异有统计学意义(P<0.01),且与病情严重程度呈正相关。结论:血清Aβ含量测定在AD诊断中有临床参考价值。

Objective： To investigate the significance of serum β-amyloid （Aβ） in the diagnosis of Alzheimer＇s disease （AD）. Methods： The saturated balance competition RIA was used to detect the content of Aβ in 30 cases of AD group （further divided into 3 groups： mild, moderate and severe subgroup） and 30 cases of intelligence normal elderly control group. All the data were statistically analyzed by SPSS 11.0 software. Results： The contents of serum AI3 in AD group and the control group were （1.36±0.60） μg/L and （0.72±0.26） μg/L respectively, the former was obviously higher than the latter. There was a statistical difference compared with the control group （P〈0.01）, and it showed a positive correlation with the severity of illness. Conclusion： The content determination of serum Aβ has clinical reference value in the diagnosis of AD.