病情知晓对胃癌患者血清Cor及IL-2的影响

Effect of patient's condition known to the serum levels of Cor,IL-2 of gastric cancer

目的:研究病情知晓对胃癌患者血清中皮质醇(Cor)、白细胞介素-2(IL-2)水平变化的影响。方法:60例经病理确诊为胃癌的患者,随机分为病情知晓对照组(C组)和病情不知晓组(N组)各30例,病情知晓对照组在入院第2天静脉采血后告知病情,病情不知晓组出院后逐渐告知病情。两组均于入院后第2天和术后第10天,晨6:00静脉采血测Cor和IL-2水平的变化。结果:与术前比较,N组Cor、IL-2两项指标没有改变(P>0.05);C组IL-2明显下降(P<0.01),Cor明显升高(P<0.01)。术后N组血清中Cor水平明显低于C组(P<0.01);IL-2水平明显高于C组(P<0.01)。结论:围术期隐瞒胃癌患者病情可防止过度应激,保持免疫力。

Objective： To study the effect of patient＇s condition known to the serum levels of Cor, IL-2 of gastric cancer. Methods： 60 eases of gastric cancer diagnosed by pathology were randomly divided into patient＇s condition known groups （group C） and unknown group （group N）, each group with 30 cases. Patients of group C were told patients condition after the second day when the vein blood was collected, while the cases of group N were gradually told the patients condition after leaving bospital. The vein blood of two groups were collected on am 6：00 at the the second day after admission and tenth day after operation, then the serum levels of Cor, IL-2 were detected. Results： Compared with preoperative levels, the postoperative levels of Cor, IL-2 of group N had no statistical difference（P〉0.05）, but the postoperative levels of IL- 2 in group C decreased obviously（P〈0.01 ）,the postoperative levels of Cor in group C increased obviously（P〈0.01 ）. After operation, the serum levels of Cor of group N were obviously lower than that of group C （P〈0.01）,but the levels of IL-2 were obviously higher than those of group C. Conclusion： Patient＇s condition unknown can prevent excessive stress, and keep the immune function.