血清骨桥蛋白水平在肺癌临床分期的表达

Study on OPN levels of serum in non-small cell lung cancer

目的探讨骨桥蛋白(ostopontin,OPN)在非小细胞肺癌患者血清中的水平及其与病理类型、临床分期的关系。方法用ELISA法对36例鳞癌组、44例腺癌组、40例肺结核组、40例健康对照组进行血清OPN水平检测。结果鳞癌组、腺癌组、肺结核组和健康对照组四者间比较差异有统计学意义(P<0.05);鳞癌组与腺癌组血清OPN水平差异有统计学意义(P<0.05),且鳞癌组血清OPN水平高于腺癌组;OPN血清水平与肺癌临床分期间存在线性相关关系(P<0.05)。结论OPN对非小细胞肺癌的诊断、肺部良恶性疾病的鉴别诊断及判定预后具有重要的临床意义。

Objective To discuss the serum levels of OPN in the patients of non - small cell lung cancer and its relationship with the type of pathology and clinical stage. Methods 36 cases of squamous cell carcinoma group, 44 cases of adenocarcinoma group, 40 cases of pulmonary tuberculosis group, 40 healthy of control group for the serum levels of OPN were detected by ELISA method. Result Compared with the control group, there were significant difference in the squamous cell carcinoma group, adenocarcinoma group and tuberculosis group （ P 〈 0.05 ）. Group adenocarcinoma and squamous cell carcinoma group were significant differences in the serum levels of OPN （ P 〈 0.05 ）, the serum levels of OPN in squamous cell carcinoma group were significantly higher than adenocarcinoma group. There was a linear relationship between the serum level of OPN and lung cancer clinical stage （P 〈 0.05）. Conclusion OPN has important clinical significance in diagnosis of non - small cell lung cancer and benign and malignant lung diseases, determining prognosis.