糖基化终末产物与冠心病、糖尿病的相关性研究

Clinical observations on correlation between advanced glycation end products and coronary heart disease or diabetes

目的探讨糖基化终末产物与冠心病、糖尿病的相关性。方法分别检测正常对照组、冠心病组、糖尿病组及糖尿病并发冠心病组的血清糖基化终末产物、糖化血红蛋白,并进行相关分析。结果各观察组血清糖基化终末产物均较正常对照组升高,且各组间的差异有统计学意义(P<0.05),糖基化终末产物与糖化血红蛋白呈正相关(r=0.738,P=0.000)。结论血清糖基化终末产物与冠心病具有相关性,并且是糖尿病心血管合并症的相关危险因素。

Objective To explore the relationship between advanced glycation end products （AGE）, coronary heart disease （CHD） and diabetes. Methods AGE and HbA1 c were tested in each group, including control, CHD, Type Ⅱ diabetes mellitus （ DM）, both CHD and DM group. Correlative analysis was carried out. Results AGE were significantly higher in each observational group compared to that in control group （ P 〈 0.05 ）. AGE was significantly positively correlated with HbAI c （ r = 0. 738, P = 0. 000）, Conclusions AGE is correlated with CHD, it＇s a risk factor relate to diabetic cardiovascular disease.