尿激酶加地塞米松治疗结核性渗出性胸膜炎的疗效观察

Urokinase plus dexamethasone for tuberculous exadative pleurisy

目的:观察胸腔内注射尿激酶加地塞米松治疗结核性渗出性胸膜炎的疗效。方法:将结核性渗出性胸膜炎106例随机分为治疗组(注射尿激酶加地塞米松组)及对照组,其中,治疗组54例,对照组52例。两组均给予抗结核、营养、支持、对症及口服糖皮质激素等常规治疗,治疗组加用尿激酶10万U和地塞米松10mg胸腔内注射,在B超定位下穿刺抽液,并与对照组比较。结果:治疗组总有效率(96.2±2.1)%,与对照组比较,差异有统计学意义(P<0.01),且治疗组胸腔积液吸收时间及住院时间均短于对照组。结论:尿激酶加地米塞松胸腔内注射治疗结核性渗出性胸膜炎取得满意疗效,且操作简便,风险低。

Objective To observe the curative effect of intrathoracic injection of urokinase plus dexamethasone for tuberculous exadative pleurisy. Method Total 106 cases with tuberculous exadative pleurisy were divided into the treatment group （ injection of urokinase plus dexamethasone group） and the control group,54 cases in the treatment group and 52 in the control group. Two groups both gave anti -tuberculosis, nutrition, support, symptomatic treatment, oral administration of sugar cortical hormone and so on, the treatment group with intrathoracic injection of urokinase 100 000 U and dexamethasone 10mg, puncturing and pumping fluid under the ultrasound localization, and compared with the control group. Results The total effective rate in the treatment group was （96. 2 ± 2. 1 ） %, and compared with the control group, the difference was remarkable （P 〈 0.01 ）. The absorption time of pleural effusion and hospital time in the treatment group were shorter than that in the control group. Conclusion Intrathoracic injection of urokinase plus dexamethasone treating tuberculous exadative pleurisy shows satisfactory effect, and the operation is easy,with low risk.