颅脑损伤患者凝血功能和肝功能测定

Determination of coagulation function and liver function in patients with craniocerebral injury

目的探讨急性颅脑损伤患者的血浆纤维蛋白原(FIB)、肝功能的变化特点及其与损伤程度的关系。方法将107例颅脑损伤患者根据临床格拉斯评分(GCS)分型分为轻型、中型和重型,并以43例正常人为对照组,测定颅脑损伤患者在24h内纤维蛋白原(FIB)和肝功能指标[谷丙转氨酶(ALT)、谷草转氨酶(AST)]并进行比较。结果急性颅脑损伤后轻、中、重型组和正常对照组血浆FIB含量差异具有统计学意义(P<0.05)。轻型组和重型组肝功能指标ALT比较差异具有统计学意义(P<0.05),重型组AST水平比较与轻型组、中型组AST水平比较差异均具有统计学意义(P<0.05)。结论颅脑损伤患者血浆纤维蛋白原和肝功能测定对颅脑损伤程度判定具有重要的参考价值。

Objective To investigate the changes of plasma fibrinogen （FIB） and liver function of the patient with acute craniocerebral injury,and their relationship with the injury degree. Methods According to clinical Glasgow score（GCS） classification, 107 patients with acute craniocerebral injury were divided into 3 groups：mild group, medium group, severe group. Forty-three healthy subjects were chosen as controls. FIB and liver function indicators, alanine aminotransferase （ALT）and aspartate aminotransferase （AST）in the patients were measured in 24 h after acute craniocerebral injury. Results The content of FIB in plasma showed significant difference between four groups （ P 〈 0. 05 ）. There was significant difference in ALT between mild group and severe group （ P 〈 0.05 ）. AST was significantly higher in severe group than in mild group and medium group（P 〈 0.05 ）. Conclusion The detection of fibrinogen（FIB） and liver function in the patients with traumatic brain injury can provide an important reference for determining the extent of brain injury.