摘要
目的观察川崎病患儿血栓调节蛋白(TM)的表达与临床意义。方法将确诊为川崎病的患儿40例设为川崎病组,再将本组根据二维超声心动图分为冠状动脉损害组和非冠状动脉损害组,分别于急性期和恢复期采集静脉血。本院体检门诊的20名健康儿童设为对照组,采集静脉血。TM浓度检测采用双抗体夹心固相酶联免疫吸附法(ELISA)。结果川崎病急性期、恢复期组患儿TM含量值升高,三组TM值变化有统计学意义(P<0.05)。急性期TM值高于恢复期(P<0.05)。冠状动脉损伤组TM含量明显高于非冠脉损伤组(P<0.01)。相关性分析显示,川崎病组患儿TM与冠脉扩张呈显著正相关,相关系数r=0.863,P<0.01。结论血栓调节蛋白在川崎病组明显升高,在心血管损伤发生、发展中起着一定的作用。
Objective To explore the variety of thrombomodulin in children with Kawasaki disease（KD） and its clinical significance. Methods Forty cases diagnosed as KD （KD group ）were divided into coronary artery lesion group and non-coronary artery lesion group by echoicardiogram. The venous blood was collected in acute stage and convalescence. Twenty normal children undergoing health examination were chosen as normal control group, and their venous blood was collected. Thrombomodulin （TM）was measured by enzyme linked immunosorbent assay. Results Compared with normal control group,TM in KD group increased significantly（ P 〈 0.05 ）. TM level in acute stage was higher than that in convalescence （P 〈 0.05 ）. Compared with non-coronary artery lesion group, TM increased in coronary artery lesion group （ P 〈 0.01 ）. TM showed a positive correlation with coronary artery lesion （ r = 0. 863,P 〈 0.01 ）. Conclusion The high level of TM in Kawasaki disease may involve in the development of coronary artery lesion.
出处
《山西医科大学学报》
CAS
2009年第8期759-761,共3页
Journal of Shanxi Medical University
关键词
川崎病
血栓调节蛋白
冠状动脉
Kawasaki disease
thrombomodulin
coronary artery
