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过氧化物酶体增殖物激活受体与血管平滑肌细胞增殖的研究进展

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摘要 过氧化物酶体增殖物激活受体(Peroxisome proliferator-activated receptors,PPARs)是核受体超家族中的一类配体依赖的核转录因子,它通过多种途径抑制血管平滑肌细胞(VSMCs)的增殖,进而在动脉粥样硬化(AS)、经皮冠状动脉介入性治疗(PCI)术后再狭窄的治疗中发挥重要作用。近年来对PPARs及其配体的研究很多,本文就其与VSMCs增殖有关的研究近况作一综述。
作者 王大杰 张延斌
机构地区 徐州医学院附属医院心内科
出处 《海南医学》 CAS 2009年第9期125-129,共5页 Hainan Medical Journal
关键词 过氧化物酶体增殖物激活受体 平滑肌细胞 细胞增殖
分类号 R329.28 [医药卫生—人体解剖和组织胚胎学]
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参考文献28

  • 1Fonseca VA, Diez J, McNamara DB, et al. Decreasing restenosis following angioplasty : the potential of peroxisome proliferator - activated receptor gamma agonists [ J ]. Diabetes Care,2004,27 ( 11 ) : 2764 - 2756.
  • 2Touvz RM, Schiffrin EL. Peroxisome proliferator - activated receptor in vascular biology - molecular mechanisms and clinical implications [ J ]. Vascul Pharmacol, 2006,45 ( 1 ) : 19 - 28.
  • 3Kota BP, Huang TH, Roufogalis BD. An overview on biological mechanisms of PPARs [ J ]. Pharmacol Res, 2005,51 (2) : 85 - 94.
  • 4Chinetti G, Fruchart JC, Staels B. Peroxisome proliferator -activated receptor(PPARs) : nuclear receptors with functions in the vascular wall [ J ]. Z Kardiol,2001,90 ( Suppl 3 ) : 125 - 132.
  • 5Starkel P, De Saeger C, Sempoux C, et al. Blunted DNA synthesis and delayed S - phase entry following inhibition of Cdk2 activity in the regenerating rat liver [ J ]. Lab Invest ,2005 ,85 (4) : 562 - 571.
  • 6Yamagishi S, Nakamura K, Matsui T, et al. Inhibitors of advanced glycation end products (AGEs) : Potential utility for the treatment of cardiovascular disease [ J ]. Cardiovasc Ther,2008,26 ( 1 ) : 50 - 58.
  • 7Moraes LA, Piqueras L, Bishop - Bailey D. Peroxisome proliferator -activated receptors and inflammation [ J ]. Pharmacol Ther, 2006,110(3):371 -385.
  • 8Diep QN, Intengan HD, Schiffrin EL. Endothelin - 1 attenuates ω3 fatty acid - induced apoptosis by inhibition of caspase 3 [ J ]. Hypertension,2000,35 ( 1 pt2) : 287 - 291.
  • 9Kintscher U, Lyon C, Wakino S, et al. PPAR α TGF - β - induced β5 integrin transcription in vascular smooth muscle cells by interacting with Smad 4[J]. Circ Res, 2002,91(11):35 -44.
  • 10Yamada H, Tsushima T, Murakami H, et al. Potentiation of mitogenic activity of platelet - derived growth factor by physiological concentrations of insulin via the MAP kinase cascade in rat A10 vascular smooth muscle cells [ J ]. Int J Exp Diabetes Res, 2002,3 (2):131 -144.

二级参考文献10

  • 1吴歆华,吴宗贵,张华.辛伐他汀与罗格列酮对动脉粥样硬化大鼠CD40和CD40L表达的影响[J].上海医学,2005,28(4):281-283. 被引量：6
  • 2Ross 8. Atherosclersis-an inflammatary diseases. N Engl J Med, I999,304(2): 115 - 126.
  • 3Mach F,Schonbeck U,Sukhova GK,et al.Functional CD40 is expressed on human vascular endothelial cells,smooth muscle cells and macrophages:implications for CD40-CD40 ligand aignaling in atherosclerosis.Proc Natl Acad Sci USA,1997,94(5):1931-1936.
  • 4Aukrust P,MUller F,Ueland T,et al.Enhanced levels of solubel and membrane-bound CD40 ligand in patients With unstable angina.Possible reflection of T lymphocyte and platelet involvement in the pathogenesis of scute coronary ayndromes.Circulation,1999,100(6):614-620.
  • 5Lutgens E,Daemen MJ.CD40-CD40L interactions in atherosclerosis.Trends Cardiovasc Med,2002,12(1):27-32.
  • 6Laman JD,de Smet BJ,Schoneveld A,et al.CD40-CD401,interactions in atherosclerosis.Immunol Today,1997,18(6):272-277.
  • 7Clark RB,Bishop-Bailey D,Estrada-Hernandez T,et al.The nuclear receptor PPAR gamma and immunoregulation:PPAR gamma mediates inbition of helper T Cell responses.J Immunol,2000,164(3):1364-1371.
  • 8Marx N,Subova G,Murghy C,et al.Macrophares in Imman atheroma contain PPAR gamma:differentiation-dependent peroxisomal proliferator-activated receptor gamma (PPAR gamma)expression and reduction of MMP-9 activity through PPAR gamma activation in mononuclear phagocytes in vitro.Am J Pathol,1998,153(1):17-23.
  • 9赵水平,李毅夫,彭道泉,聂赛,周宏年.急性冠脉综合征单核细胞过氧化物酶体增生激活型受体γ基因表达及其与细胞黏附分子相关性研究[J].中华心血管病杂志,2001,29(10):580-583. 被引量：10
  • 10严金川,吴宗贵,张玲珍,李莉,仲人前,孔宪涛.CD40配体高表达与不稳定型心绞痛之间的关系[J].中国动脉硬化杂志,2001,9(5):409-412. 被引量：16

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海南医学
2009年 第9期

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