重症急性胰腺炎肠黏膜屏障功能障碍的发生机制

Mechamism of severe acute pancreatitis associated gut barrier dysfunction

重症急性胰腺炎时常并发肠黏膜屏障功能障碍,导致肠道细菌移位,内毒素血症,胰腺继发感染,造成对机体的"二次打击"。炎症介质、微循环障碍、腹内高压、细胞凋亡等因素共同作用可能是肠黏膜屏障功能障碍的机制。

The gut barrier function is always impaired in the early stage of severe acute panereatitis. Gut barrier dysfunction could result in bacterial transloeation, endotoxemia and secondary infection of pancreatitis, which cause ＂second attack＂ to the body. Inflammatory mediators, microeirlation failure, intra- abdominal hyper- tension, cell apoptosis and other factors may together contribute to gut barrier dysfunction.