方酸与芳伯胺在有水介质中的脱水缩合反应

THE DEHYDRATION CONDENSATION REACTIONBETWEEN SQUARIC ACID AND PRIMARY ARYLAMINE IN H_2O OR DMSOH2O

与通常的脱水缩合反应条件不同，而以Ｈ２Ｏ或以Ｈ２ＯＤＭＳＯ（１∶２，体积比）为介质，加热下方酸与芳伯胺之间可顺利实现脱水反应．方酸与芳伯胺的摩尔比为１∶２．２时，主要生成双取代产物异方酰胺；在１∶１的情况下，主要生成单取代产物Ｎ芳基氮氧方酸．

The dehydration reaction between squaric acid and primary arylamine are easity formed when heated in H_2O or H_2ODMSO(1∶2,Volume ration),it is quite different from the normal condition of dehydration condensation reactions.Disubstituted isosquaramide was obtained as main product when the molar ratio of squaric acid to primary arylamine was 1.0∶2.2;and monoamide of squaric acid (Narylnitrogenoxosquaric acid) was obtained as main product when the ratio was 1∶1.So this synthetic reaction is a very simple and effective route for preparation of concerned compounds.