从天然酒石酸合成新的具有C_2对称性的1,2-手性双膦配体

Synthesis of new 1,2-diphosphines Ligand with C_2 chirality from natural tartaricacid

以廉价的天然酒石酸为原料，经过八步反应，合成了具有C_2对称性的1，2-双齿手性膦配体，其结构经元素分析、IR、~1H、^（31）PNMR确证。通过构象分析及与其它类似结构的配体相比较，预计由其和过渡金属形成的催化剂体系能催化不对称氢化、不对称氢甲酰化和不对称氢酯基化反应，并且用于（S）－DOPA和（S）-苯丙氨酸的合成，光学产率将大于91％。

We preparaion of 1, 2 - diphosphine possessing C2 symmetry through eight steps fromcheaper natural tartaric acid was successful . And every intermediate products structure has been ascertained by element analysis、 IR、 and 1H、31 PNMR, respectively. Compared with other sindlar ligand,The catalst systems formed with the new ligand synthesind and transitional metals could used for catalyzing asymmetric hydrformylation、 asymmetric hydrogenation and asymmetric hydroesterification. The prepared L - DOPA and (S) - phenyl alanine use it, over 90% optical yields. will be obtained