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神经系统40Hz振荡的一个物理模型

A BIOPHYSICAL MODEL OF OSCILLATION IN γ BAND IN NEURONAL SYSTEM
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摘要 采用一个简化神经网络物理模型,对这种40Hz同步振荡的产生,及其相对稳定性特性进行了研究,得到一个全局耦合的神经网络系统,自然具有40Hz同步振荡的特性,并且。 Synchronous oscillations with frequencies in the γ band (30 - 70Hz), usually regarded as 40Hz synchronous oscillations, have been discovered recently in experiments in various neuronal systems. It has been found experimentally that large-scale synchronized neuronal activity is often accompanied with oscillatory firing patterns in this intriguing frequency band. For example, it can be generated spontaneously in visual cortex of anesthetized cat and awake monkey, in the motor and somatosensory cortex of human, especially during the period of focused attention, as well as in the sensorimotor cortex during the response to outside stimulus. A lot of cerebration functions, such as binding of scene segmentation, perplex object representation, and sensorimotor integration are regarded as being achieved by the synchronous oscillatory activities of a group of neurons. Up to now, the origin of the synchronized 40Hz oscillation has not been studied deeply. Few studies about it have been reported. Most models about it have not related their results with time. In this paper, we have made a study on the origin of the 40Hz synchronous oscillations with a biophysical model and the relation between the frequency band and system coupling patterns as well as the stimulus. Based on an established Hindmarsh-Rose model for single neuron, we construct a network comprising of 200 simulated neurons with globe couplings, assigning the coupling between neurons distributed in a range with different inhibitory rate. We calculate the spatio-temporal patterns of various systems with different simulated stimulus and system coupling pattern in order to compare our results with established experiments. Referring to the power spectrum density of respondent average synapse currents, we find that the system always presents the 40Hz frequency features as long as the existence of global reciprocal connections between neurons, and periodic mean-field synaptic currents. Furthermore, the oscillations show strong stability in versatile neuronal systems for various stimuli. With coupling, synchronization in 40Hz oscillations can be established and last for a considerable time. It is the intrinsic character of a coupling system that is applicable to most neuronal systems.
作者 陈光 王炜
出处 《南京大学学报(自然科学版)》 CAS CSCD 1998年第4期419-428,共10页 Journal of Nanjing University(Natural Science)
关键词 神经网络系统 40Hz同步振荡 全局关联耦合 模型 Neuronal system, 40Hz synchronous oscillation, Global reciprocal connections, Synaptic currentsInhibitory rate
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参考文献5

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