手性毛细管气相色谱跟踪苯乙酮不对称催化氢化反应过程

Analytical Control of Asymmetric Transfer Hydrogenation of Acetophenone using Chiral Capillary Gas Chromatography

手性毛细管气相色谱跟踪苯乙酮不对称催化氢化反应过程许翩翩阮源萍高景星（厦门大学化学系固体表面物理化学国家重点实验室物理化学研究所厦门３６１００５）在开发研究芳香酮氢化反应的新型手性催化剂时，通常采用苯乙酮不对称催化氢化生成苯乙醇的反应效率来评价手性氢...

This paper deals with the process analysis of asymmetric transfer hydrogenation of acetophenone by using Chiral capillary gas chromatography. The solvents, acetophenone and phenylethanol enantiomers were wellseparated on a Chrompack CPcyclodextrinβ236M19 column with FID detector. The racemic phenylethanol was determined and the relative content of the enantiomer was 50.1∶49.9(n=6). The chromatographic separation enable accurate determination of e.e. value and conversion(%) of acetophenone. The absolute configuration of the major enantiomer of phenylethanol was determined from the elution order. This method may be suitable for research in process of asymmetric transfer hydrogenation of arometic ketones.