帕罗西汀辅助治疗功能性消化不良

Paroxetine in the Treatment of Functional Dyspepsi

目的:观察帕罗西汀佐治功能性消化不良(FD)的临床效果。方法:将70例FD随机分为两组,对照组(34例)予多潘立酮10mg每日3次口服,奥美拉唑20mg每日2次口服;治疗组(36例)在对照组治疗的基础上加用帕罗西汀10～20mg,每日1次口服。两组疗程均为4周,观察两组效果。结果:治疗组近期临床治愈21例,显效10例,有效3例,无效2例,近期临床治愈率为58.3%,总有效率为94.4%;对照组近期临床治愈8例,显效8例,有效10例,无效8例,近期临床治愈率为23.5%,总有效率为76.5%。两组近期临床治愈率比较差异有统计学意义(P<0.01),总有效率比较差异亦有统计学意义(P<0.05)。结论:在FD常规治疗基础上,联合帕罗西汀抗抑郁治疗,可起到协同作用,对FD有良好的疗效。

Objective：To observe the clinical effect of treating functional dyspepsia with Paroxetine. Methods：70 FD patients were randomly divided into 2 groups ： the treatment group （ n = 36） and the control group（ n = 34）. The patients in the control group were given 10 mg of Domperidone t. i.d. and 20 mg of Prilosec twice a day orally and the patients in the treatment group were given the same medication as the control group plus 10-20 mg of Paroxetine once a day in a 4-week period of treatment. The effects between the two groups were compared. Results：In the treatment group,the short-term clinical cure rate was 58.3% （21 cases） and the total effective rate was 94.4% （ 10 excellent,3 effective and 2 invalid）, In the control group the short-term cure rate was 23.5% （8 cases）and the total effective rate was 76.5% （8 excellent, 10 effective and 8 invalid）. The short-trem cure rates and the total effective rates in the 2 groups showed difference of statistical significance （ P 〈 0.01 vs P 〈 0.05 ）. Conclusion： Paroxetine contributes to the treatment of functional dyspepsia.