药物中间体乙酸苯酯的合成

Synthesis of Phenyl Acetate as Drug Intermediates

以苯酚、乙酰氯为原料直接反应合成乙酸苯酯,探讨了各种因素对合成反应的影响。结果表明,最佳工艺条件为:n(C6H6O):n(C2H3OCl)=1:1.2,环己烷作溶剂,溶剂用量40mL(相对于0.15molC6H6O),反应温度20℃、时间5h。在此条件下,乙酸苯酯的产品收率达到95.55%,产物经元素分析、红外光谱分析确认。

The phenyl acetate was synthesized from phenyl hydroxide and acetyl chloride by direct esterification and the factors influencing the synthesis were studied.Results showed that the optimal conditions were:n(C6H6O):n(C2H3OCl)=1:1.2,the amount of solvent cyclohexane was 40 mL(compared to 0.15 mol C6H6O),the reaction temperature was 20℃,and the reaction time was 5 h.The yield of the product was 95.55% which was analyzed qualitatively by means of elemental analysis and IR.