73例2型糖尿病患者C反应蛋白和微量清蛋白检测分析

The relationship between c-reactive protein and microalbuminuria in type 2 diabetes mellitus

目的探讨C反应蛋白与2型糖尿病微量清蛋白(mALB)尿症的关系及意义。方法应用己糖激酶法、速率透射免疫比浊法和放射免疫法分别测定73例2型糖尿病患者和46例健康对照组的空腹血糖、C反应蛋白和尿微量清蛋白含量。按微量清蛋白含量水平分为高微量清蛋白组(A组)和正常微量清蛋白组(B组),比较C反应蛋白水平。利用SPSS14.0统计软件包对各项指标进行t检验和相关分析。结果2型糖尿病患者组的空腹血糖,C反应蛋白和尿微量清蛋白水平均显著高于健康对照组,差异有统计学意义(P<0.01);A组C反应蛋白水平显著高于B组和健康对照组(F=8.535,P=0.005;F=7.952,P=0.006);B组与健康对照组的C反应蛋白水平差异无统计学意义(F=3.159,P=0.080);2型糖尿病组的C反应蛋白水平与尿微量清蛋白水平呈显著性正相关(r=0.778,P<0.01)。结论检测尿微量清蛋白是诊断糖尿病早期肾脏微血管病变的敏感指标,血清C反应蛋白水平与尿微量清蛋白水平具有一定的相关性,联合检测C反应蛋白水平和尿微量清蛋白水平对2型糖尿病肾脏微血管病变的发生及病情的监测有重要临床价值。

Objective To investigate the C-reactive protein and microalbuminuria in type 2 diabetes mellitus and its significance. Methods The content of the fasting blood glucose,C-reactive protein and urinary albumin conten of 73 cases of type 2 diabetic patients and 46 healthy control group was detected by means of hexokinase,transmission rate immunoturbidimetric assay and radioimmunoassay retrospectively. In accordance with the different levels of microalbuminuria,they were divided into two groups （A group） and normal microalbuminuria group （B group） respectively, and the level of C-reactive protein was compared. All the indicators were involved in the t test and correlative analysis by statistical packages SPSS14.0 . Results The outcome of the fasting blood glucose,C-reactive protein and urinary albumin of the patients with type 2 diabetes was significantly higher than that of the healthy control group （P〈0.01） ; C-reactive protein level of Group A was significantly higher than that of Group B and the healthy control group （F= 8. 535,P=0. 005;F=7. 952,P=0. 006） ; the C-reactive protein level of Group B and the healthy control group has no significant difference （F= 3. 159 ,P=0. 080）; the C-reactive protein levels and the level of urinary albumin of the group with type 2 diabetes mellitus were of significantly positive correlation （r=0. 778, P〈0. 01）. Conclusion The detection of microalbuminuria is a sensitive indicator of early diagnosis of diabetic kedney microvascular disease,and serum C-reactive protein level and the level of urinary albumin has a certain relevance with each other. So it is of clinical value in minitoring the occurrence of renal microvascular disease by the combined detection of C-reactive protein level and the level of urinary albumin in type 2 diabetes.