微创穿刺粉碎清除术治疗颅内血肿时间窗的动物实验研究

Research of curative effect in experimental model of the minimal invasive operation of eliminating intracranial hematoma in different periods

目的探讨微创穿刺粉碎清除术在不同时间段清除颅内血肿的效果差别。方法将24只体质量(10±1)kg的家犬(雌雄不分)随机分成4组建立脑出血模型,在造模成功后3h(A组)、6h(B组)、12h(C组)、18h(D组)内进行微创穿刺粉碎血肿清除术;于造模前、造模后3h、微创术后1周作运动诱发电位运动功能的变化。结果A组和B组术后7d运动诱发电位恢复较快,分别为(15.60±1.91)ms和(19.35±2.55)ms,与同组的造模后3h检测结果相比较,差异有统计学意义(P<0.01),与C组、D组相比差异也有统计学意义(P<0.01)。结论超早期进行微创穿刺粉碎清除术清除颅内血肿,可以促进运动功能尽快恢复(运动诱发电位潜伏期恢复至正常水平)。

Objective To explore curative effect in experimental model of the minimal invasive operation of eliminating intracranial hematoma in different stages. Methods Twenty-four dogs with the bady weight of 10± 1 kgs randomly divided into 4 groups,the operation of the minimal invasive conducted out of eliminating intracranial hematoma operated at 3h（Group A）,6h（Group B）,12h（Group C）, 18h（Group D） after the model was successfully constructed. Before the model was made,3 hours after it and a week after the mimal operation,MEP was checked to explore the diversity of the motor function rusulted in the damage of the motor fiber. Results The MEP recovery of group A and B were faster,with the rate of （15. 604±1, 91）ms and （19.35±2.55）ms respectively,there was a significant difference compared with the same group A after the model was made and there was also a significant difference compared with,the group of C and D（P〈0.01）. Conclusion The operation at hyper-earlier period of eliminating intracranial hemorrhage could promote the motor function as soon as possible.