羟苯磺酸钙胶囊联合复方丹参滴丸治疗糖尿病性视网膜病及肾病的疗效

Effects of calcium dobesilate capsule combining compound dansen dropping pill in the treatment of diabetic retinopathy and diabetic nephyopathy

目的观察羟苯磺酸钙胶囊联合复方丹参滴丸治疗糖尿病性视网膜病变及肾病的疗效。方法将65例2型糖尿病并发糖尿病性视网膜病及肾病患者随机分为2组,对照组(口服复方丹参滴丸每次270mg,tid);治疗组(口服复方丹参滴丸每次270mg+羟苯磺酸钙胶囊每次500mg,tid),均连服3个月;观察2组患者治疗前后眼底的变化、血流变、血肌酐、尿素氮及24h尿蛋白定量的变化。结果眼底病变的改善,治疗组比对照组明显增多,恶化者明显减少(P<0.01);治疗组降低血液粘稠度的疗效更加明显;联合治疗更能减少尿蛋白的排出、降低血肌酐与尿素氮水平,减轻肾损害,保护肾功能。结论复方丹参滴丸联合羟苯磺酸钙胶囊治疗糖尿病性视网膜病及肾病疗效优于单用复方丹参滴丸治疗。

Objective To evaluate the effect of calcium dobesilate capsule combining compound dansen dropping pill treating diabetic retinopathy and diabetic nephyopathy. Methods Sixty-five patients with diabetic retinopathy and diabetic nephyopathy were randomlied into two groups, control group （ compound dansen dropping pill po 500 mg, tid, n = 32） ; trial group （ compound dansen dropping pill po 500 mg ＋ calcium dobesilate po 270 mg,tid, n = 33 ） for three months. The change of eye ground,blood rheology, serum creatinine, urea nitrogen,24 hours urine protein were Observe. Results Trial group were obviously muh than control group about eye ground improved, ang aggravated obviously reduced. （P 〈 0.01 ）. Trial group degrade blood rheology and urine protein, discharge degrade serum creatinine and urea nitrogen, to lessen kidney damage, protection kidney were more obviously than control group. Conclusion The effect of treating diabetic retinopathy and diabetic nephyopathy by combining calcium dobesilate pill and compound dansen dropping pill were good than take compound dansen dropping pill alone.