代谢性核受体功能及转录活性调控机制的研究进展

Progress in the function and transcriptional regulation mechanism of metabolic nuclear receptor

代谢性核受体隶属于配体依赖性转录因子超家族,其下游效应靶基因均为主司异源性药物/毒物及内源性激素代谢功能的酶及转运蛋白,可对临床药物治疗效果及疾病易感性产生重要的影响。近年来有关代谢性核受体的功能及其转录活性调控的机制等已开始受到了关注,并已成为药物代谢动力学及临床肝病治疗学领域新的研究热点。

Metabolic nuclear receptors belong to a superfamily of ligandactivated transcription factors, which regulates the expression of enzyme and transport protein responsing for metabolizing xenobiotics and endogenous hormones, contributed to the therapeutic effect of drug and susceotility for diseases. Recently, it has been interested in the function of the metabolic nuclear receptors and their transcriptional regulation mechanism by the ligands, and the researches have been focused on pharmacokinectics and clinical hepatopathy treatment field.