妊娠妇女纤维蛋白原含量变化的特性分析

Analysis of content changes of plasma fibrinogen in pregnant women

目的:通过研究妊娠妇女包括正常孕产妇和妊高征(Hypertensive syndrome of pregnancy)个体血浆中纤维蛋白原(Fibrinogen,Fg)含量的变化,明确临床监测Fg含量对妊娠期妇女的重要价值。方法:选取148例妊娠妇女,其中正常孕产妇60例,妊高征孕产妇30例和58例非孕产妇血浆标本,采用凝固法,进行Fg含量的测定,并与非孕产妇的健康对照组做比较。结果:与对照组相比,妊娠妇女体内Fg的含量显示有不同程度的增高。正常孕产妇组与健康对照组比较,有较明显差异(P<0.05);妊高征组与健康对照组比较有极显著差异(P<0.01)。结论:妊娠妇女包括正常和妊高征个体血浆中Fg的含量可明显增多。说明,妊娠妇女机体内可出现凝血一抗凝以及纤溶等系统的一系列改变甚至失衡。提示孕产妇特别是妊高征患者,应随时监测Fg含量,以便能密切观察其凝血功能,预防和治疗出血,降低DIC的发生率,确保临床安全。

Objective： Through studying plasma fibrinogen（Fg）in pregnant women,include normal and hypertensive pregnancy,realizing clinical detecting Fg level to pregnant women is very important.Methods：Selecting 148 cases,amongthem：60 normalpregnancy,30 hypertensive and 58 nonpregnancy,Fg in their plasma samples were detected by caky method and were compared with healthy group.Results：Comparing with healthy group,Fg levels in pregnant women plasma show different degree raise.Normal pregnancy is obvious otheness（P〈0.05）,hypertensive pregnancy is marked otherness（P〈0.01）.Conclusion：Plasma Fg levels in normal and hypertensive pregnant women are raised,it states,that there are a series of changes of coagulating-anticoagulating and fibrous-dissolvable system in pregnant women bodies,even unbalance.Caution pregnant women,their Fg levels should be tested at any time in order to observe their coagulating,prevent and cure their bleeding,reduce their DIC occurrence and ensure their clinical security.