重庆市O139型霍乱弧菌耐药性监测分析

Analysis of antibiotic resistance of Vibrio cholera O139 strains in Chongqing

目的：了解2000-2005年重庆市O139型霍乱弧菌的耐药性和耐药性的变迁。方法：采用K-B法检测118株O139型霍乱弧菌对16种抗菌药物的敏感性。结果：重庆地区O139型霍乱弧菌对丁胺卡那、诺氟沙星和环丙沙星100%敏感,对四环素、复方新诺明、痢特灵、吡哌酸、新霉素、强力霉素和链霉素的耐药率达到了80.51%-88.98%。2005年分离菌株对妥布霉素、氨苄西林、氯霉素的耐药率较2002年和2003年有所增高,而链霉素的耐药率较2003年和2002年有所下降。结论：重庆市O139型霍乱弧菌对四环素、复方新诺明、痢特灵、吡哌酸、新霉素、强力霉素和链霉素耐药严重。长期对霍乱弧菌的耐药性进行监测和动态分析,可以为霍乱弧菌的流行病学研究以及对霍乱的监控和防治提供依据。

Objective： To study the antibiotic resistance of Vibrio cholerae O139 strains in Chongqing from 2002 to 2005.Methods：Susceptibility to 16 antimicrobial agents was tested by K-B method in 118 Vibrio cholerae O139 strains.Results：The strains had 100% sensitivity to amikacin,norfloxacin and ciprofloxacin,and the drug resistance rate to tetracycline,trimethoprim,furazolidone,pipemidic acid,neomycin,doxycycline hydrochloride and streptomycin was from 80.51% to 88.98%.The strains isolated from 2005 had higher drug resistance rate to tobramycin,Ampicillin and Chloramphenicol than the strains isolated from 2002 and 2003,but has less drug resistance rate to the Streptomycin.Conclusion：This Vibrio cholerae O139 strains has high drug resistance rate to tetracycline,trimethoprim,furazolidone,pipemidic acid,neomycin,doxycycline hydrochloride and streptomycin in Chongqing.The dynamic analysis and surveillance of the antibiotic resistance for a long time can provide the basis for the epidemiologic studies on and the control of Vibrio cholerae O139.