摘要
DNA胞嘧啶5-甲基化是高等植物主要的DNA甲基化修饰形式,该反应过程需要甲基转移酶催化。目前已知的植物胞嘧啶5-甲基转移酶可分为三类:第一类甲基转移酶1,主要功能是维持甲基化;第二类染色质甲基转移酶,是植物特有的一种甲基化酶;第三类域重排甲基转移酶,在DNA从头甲基化过程中有重要作用。本文详细介绍了它们的结构、功能及进化关系。
The addition of a methyl group to the carbon 5 of cytosine residues is the most common modification of DNA in higher plants. Plant DNA methyltransferases can be divided into three classes based on their linear domain arrangement: DNA methyltransferase (MET), chromomethyltransferase (CMT) and domains-rearranged methyltransferase (DRM). MET and CMT are responsible for the maintenance of methylation, and the latter has been found only in plants presently; DRM appears to be the principal de novo methyltransferase. In this article, the structure, function and evolutionary aspects of the main plant DNA methyltransferases are analyzed in detail.
出处
《生命的化学》
CAS
CSCD
北大核心
2009年第4期534-538,共5页
Chemistry of Life
基金
河南省教育厅科技攻关项目(2009B210001)资助
关键词
甲基转移酶1
染色质甲基转移酶
域重排甲基转移酶
maintenance DNA methyltransferese
chromomethyltransferase
domains-rearranged methyltransferase