摘要
油酰乙醇胺(oleoylethanolamide,OEA)是一种内源性脂肪酸乙醇胺,可减少食物摄取和体重增加。OEA的合成和释放受到食物摄取的调节:在进食后增加,而在禁食期间减少。OEA通过激活瞬时受体电位香草酸亚型1、过氧化物酶体增殖激活受体α以及增加脂肪酸移位酶表达等实现其生物学功能。OEA对脂类代谢的调节作用显示出其在肥胖治疗方面具有巨大潜力。
Oleoylethanolamide （OEA） is an endogenous fatty acid ethanolamide, which reduces food intake and body weight gain. The biosynthesis and release of OEA are stimulated by feeding and reduced during fasting. The biological mechanism of OEA can be achieved through activating transient receptor potential vanilloid type 1 （TRPV1）, peroxisorne proliferator-activated receptor a （PPARα） and increasing expression of fatty acid translocase （FAT/CD36）. The regulated function of OEA on lipid metabolism indicates the huge potential of OEA on obesity treatment.
出处
《生命的化学》
CAS
CSCD
北大核心
2009年第4期614-617,共4页
Chemistry of Life
关键词
油酰乙醇胺
食物摄取
脂类代谢
肥胖
oleoylethanolamide
food intake
lipid metabolism
obesity
