不同类型鸡新城疫La Sota疫苗的免疫应答比较

Comparing the Immune Response of Different Type of La Sota Vaccines against Newcastle Disease Virus

A、B、C、D组SPF鸡分别接种La Sota加佐剂活疫苗,未加佐剂活疫苗,氢氧化铝胶佐剂苗和油佐剂灭活疫苗,通过采集血清进行红细胞凝集抑制试验,测定其抗体水平,并进行比较。结果表明,La Sota加佐剂活疫苗组可产生较高的抗体滴度,并持续较长时间;而未加佐剂疫苗组血清阳转较弱,且持续时间较短;油佐剂灭活疫苗组抗体滴度最高,维持时间最长。

Five groups of SPF chicks were equally divided into A, B, C, D and E. Group A was given adjuvanted La Sota live vaccine. B was given La Sota live vaccine without adjuvant; C and D were given La Sota inactived vaccine with Aluminium Hydroxide Gel Adsorbed and emulsion respectively. Group E was unvaccinated as control. Then five groups were subjected to hemagglutination inhibition （HI） test for assessment of antibody level against NDV. It was showed that group A was detected a comparatively higher level of antibody for a longer period. However, the sero-conversion of group B was comparatively poor. The peak of antibody against NDV La Sota strain in group D was highest and maintained more time than the others groups.