试验性肉仔鸡氟苯尼考中毒的病理学研究

Pathological Study of Florfenicol Poisoning in Experimental Broiler

以7日龄肉仔鸡为试验动物,在饲料中添加不同剂量氟苯尼考(200、400、8002、000 mg/kg饲料(以氟苯尼考计)),对试验性氟苯尼考中毒的肉仔鸡的临床症状、剖检变化和组织病理学进行观察。结果表明,氟苯尼考中毒肉仔鸡表现腹泻,采食量减少,饮欲增加,腿无力,跗关节着地,站立不稳。剖检可见病鸡肠道大部分充血、出血,肝脏严重肿大,变性、坏死,呈土黄色,肾脏肿大、出血,腹腔有大量积液;病理组织学变化可见肝、肾等颗粒变性、脂肪变性。

7-day-old broilers were chosen as the experimental animals, and they were fed with feeds containing different doses of Florfenicol （200, 400, 800, 2000 mg/kg feed） for 14 consecutive days to develop a poisoning model. Clinical symptoms, autopsy and histopathological changes were observed. The results showed that Florfenicol broiler performance poisoning diarrhea, reduced feed intake, drink increased; leg weakness and tarsus and stand unstable. Autopsy of the majority of chickens showed that intestinal hyperemia, hemorrhage, severe liver enlargement, degeneration and necrosis, was khaki-colored, kidney swelling, bleeding, had a large number of peritoneal effusion; histopathological changes in liver, kidney and other granular de- generation, fat degeneration.