抗-R7V抗体与HIV感染后疾病进展关系的初步研究

Correlation between anti-R7V antibody existence and disease progression in Chinese HIV carriers

目的初步了解人类免疫缺陷病毒(HIV)感染者血清抗-R7V抗体阳性与疾病进展之间的相关性。方法检测HIV感染者的抗-R7V抗体,根据结果分为阳性、阴性和灰区3组。跟踪随访,观察各组病例的CD4+T细胞计数和病毒载量变化,以及进行高效抗逆转录病毒治疗(HAART)的情况,进行组间比较。结果44例感染者中,发现9例抗-R7V阳性,阳性率为20.45%。其中7例感染HIV均超过10年。经过平均28.5个月随访,阳性组CD4计数下降幅度和开始HAART治疗的患者比例均显著低于阴性组。结论HIV感染者中抗-R7V阳性率为20.45%,该抗体阳性和HIV感染后疾病缓慢进展之间存在着较高的相关性。

Objective To study the correlation between anti-R7V antibody existence and disease progressing in Chinese HIV carriers. Methods All cases were divided into three groups by detecting anti-R7V antibody： positive, gray zone and negative. They were followed up to observe the change of CD4 count, viral load and outcomes of HAART. Results Of 44 HIV carriers,9（20.45%）were detected as anti-R7V antibody positive,seven of whom had contracted HIV more than 10 years. The extent of CD4 count reduction and the proportion of the HIV carriers who received HAART in the positive group were significantly lower than in the negative group. Conclusion The positive rate of anti-R7V antibody in Chinese HIV carriers is 20.45%. There is good correlation between anti-R7V antibody existence and disease progression in them.