不同类型单纯性肥胖者近端胃功能特征分析67例

Proximal gastric function in volunteers with different types of simple obesity:an analysis of 67 cases

目的:探讨不同类型单纯性肥胖者近端胃功能的变化特征.方法:将67例单纯性肥胖志愿者根据饮食行为分为3组:肥胖伴暴食组(A组)、肥胖饮食正常组(B组)、肥胖伴功能性消化不良组(C组);采用电子恒压器,对3组肥胖者和D组(32例正常体质量健康志愿者)进行胃底机械性扩张,观察其可耐受容积和压力及顺应性的变化.结果:A组初始容积和最大耐受容积显著大于D组(t=-6.63,-5.20,均P<0.01),而C组显著低于D组(t=3.48,2.11,均P<0.01).C组初始胃内压、最大耐受胃内压低于D组(t=2.09,2.08,均P<0.05);A组初始及最大耐受顺应性显著大于D组(t=2.44,-5.56,均P<0.01),C组显著低于D组(t=2.44,2.32,均P<0.05).结论:暴食患者肥胖形成的主要原因是胃容积增加、顺应性增高、容受性增强及饱感延迟发生.

AIM： To analyze the characteristics of changes in proximal gastric function in volunteers with different types of simple obesity. METHODS： Sixty-seven volunteers with simple obesity were divided into three groups, namely, group A （volunteers with binge eating）, group B （volunteers with normal diet） and group C （volunteers with functional dyspepsia）. Thirtytwo non-obese healthy volunteers formed the control group （group D）. Gastric barostat studies were then performed to record the changes in gastric capacity, intragastric pressure and gastric compliance in response to mechanical distension. RESULTS： The initial volume （Ⅳ） and maximal tolerance volume （MV） in group A were significantly larger than those in group D （t=-6.63 and -5.20, respectively; both P 〈 0.01）, whereas these two parameters in group C were significantly lower than those in group D （t = 3.48 and 2.11, respectively; both P 〈 0.01）. The initial intragastric pressure （IP） and the maximal tolerance pressure （MP） in group C were significantly lower than those in group D （t = 2.09 and 2.08, respectively; both P 〈 0.05）. The initial gastric compliance （IC） and the maximal tolerance compliance （MC） in group A were significantly higher than those in group D （t = 2.44 and -5.56, respectively; both P 〈 0.01）, whereas these two parameters in group C were significantly than those in group D （t = 2.44 and 2.32, respectively; both P 〈 0.05）. CONCLUSION： The main reason for the development of obesity in binge eaters is due to an increase in gastric capacity, compliance and accommodation as well as a delay in satiety.