窄谱中波紫外线联合雷公藤片治疗156例手部湿疹疗效观察

Analysis on Effect of NB-UVB Combined with Tripterygium Glycoside on 156 Patients with Hand Eczema Treated

目的:观察窄谱中波紫外线(NB-UVB)与雷公藤片联合治疗手部湿疹的疗效及不良反应。方法:采用开放对照研究方法,将156例患者分为A、B两组。A组80人给予雷公藤片,B组76人给予NB-UVB皮损照射+口服雷公藤片治疗,疗程4周。结果:治疗结束时与治疗前比较,A组患者瘙痒、皮损、部位的积分和总积分分别下降70%、73.1%、70.5%和71%;而B组下降87.1%、91.7%、88.3%和89.1%。治疗前后组内比较及治疗后组间比较,其平均积分差异均有统计学意义(P<0.05)。治疗过程中未见NB-UVB局部照射的不良反应,雷公藤片口服组主要副作用是:5%患者血白细胞减少、5%女性月经量减少,3.8%患者AST一过性升高,但都为自限性。结论:NB-UVB照射联合雷公藤片治疗手部湿疹可以提高疗效、缩短疗程、安全性好,值得临床选用。

Objective：To study the effect on hand eczema treated with Narrow- band （NB） UVB and Tripterygium Glycoside and analyze side -effect during treatment. Methods： 156 patients with hand eczema were enrolled in study. The patient group was divided into two groups （group A and group B） in open control -placebo clinical trial. In group A, 80 patients were treated with Tripterygium Glycoside only, and in group B, 76 patients were treated with irradiating NB -UVB and oral tripterygium glycoside. Therapy effect was evaluated after four weeks treatment. Results：Average general severity score for group A decreased from 8.11 before treatment to 2.35 post - treatment, and from 8.05 before treatment to 0.88 post - treatment for group B respectively. There is a statistically significant difference in decreased -value between these two groups （P 〈 0.05）. Therefore, we found that NB -UVB combined with Tripterygium Glycoside is an alter- native, safety means for hand eczema. The common side effects were decreased white blood cell （WBC） count（occurance in 5% of patients）;menstrual dysfunction （5%） and abnormal serum ALT/AST（3.5% ）. However, all of them were self - limited. Conclusion： NB - UVB combined with oral Tripterygium Glycoside is a safe and effective alternate means to treat hand eczema.