乳腺癌VEGF-C mRNA的表达与淋巴结转移的关系

Correlation between VEGF-C mRNA expression and lymph node metastasis in breast cancer

目的探讨乳腺癌血管内皮生长因子C(VEGF-C)的表达与乳腺癌淋巴结转移等临床病理指标之间的关系。方法用逆转录聚合酶链反应(RT-PCR)法检测60例乳腺浸润性导管癌VEGF-C mRNA的表达情况,取15例乳腺纤维腺瘤标本作为对照。结果乳腺癌组VEGF-C mRNA的阳性表达率及表达程度明显高于对照组(P均<0.01);乳腺癌淋巴结转移组VEGF-C mRNA的表达率及表达程度高于淋巴结非转移组(P均<0.05);VEGF-C mRNA的表达与乳腺癌淋巴结转移呈正相关(r=0.638,P<0.01)。结论乳腺癌中VEGF-C mRNA的表达水平增高;VEGF-C mRNA的表达促进乳腺癌淋巴结转移。

Objective To study the expression of vascular endothelial growth factor C （VEGF-C） in breast cancer and its correlation with clinicopathological indexes of lymph node metastasis. Methods Reverse transcription polymerase chain reaction （RT-PCR） method was adopted in detecting VEGF-CmRNA expression in 60 cases of breast infiltrative tubular cancer. We took 15 cases of breast fibroadenoma as controls. Results The positive rate and degree of VEGF-CmRNA expression were higher in the breast cancer group than in the control group （P 〈 0.01）. VEGF-CmRNA expression was significantly higher in the lymph node metastasis-positive group than in lymph node metastasis-negative group （P 〈 0.05）. VEGF-CmRNA expression was positively correlated with lymph node metastasis （r = 0.638, P 〈 0.01）. Conclusion VEGF-CmRNA expression was higher in breast cancer and it promoted lymph node metastasis in breast cancer.