摘要
目的探讨乳腺癌血管内皮生长因子C(VEGF-C)的表达与乳腺癌淋巴结转移等临床病理指标之间的关系。方法用逆转录聚合酶链反应(RT-PCR)法检测60例乳腺浸润性导管癌VEGF-C mRNA的表达情况,取15例乳腺纤维腺瘤标本作为对照。结果乳腺癌组VEGF-C mRNA的阳性表达率及表达程度明显高于对照组(P均<0.01);乳腺癌淋巴结转移组VEGF-C mRNA的表达率及表达程度高于淋巴结非转移组(P均<0.05);VEGF-C mRNA的表达与乳腺癌淋巴结转移呈正相关(r=0.638,P<0.01)。结论乳腺癌中VEGF-C mRNA的表达水平增高;VEGF-C mRNA的表达促进乳腺癌淋巴结转移。
Objective To study the expression of vascular endothelial growth factor C (VEGF-C) in breast cancer and its correlation with clinicopathological indexes of lymph node metastasis. Methods Reverse transcription polymerase chain reaction (RT-PCR) method was adopted in detecting VEGF-CmRNA expression in 60 cases of breast infiltrative tubular cancer. We took 15 cases of breast fibroadenoma as controls. Results The positive rate and degree of VEGF-CmRNA expression were higher in the breast cancer group than in the control group (P 〈 0.01). VEGF-CmRNA expression was significantly higher in the lymph node metastasis-positive group than in lymph node metastasis-negative group (P 〈 0.05). VEGF-CmRNA expression was positively correlated with lymph node metastasis (r = 0.638, P 〈 0.01). Conclusion VEGF-CmRNA expression was higher in breast cancer and it promoted lymph node metastasis in breast cancer.
出处
《西安交通大学学报(医学版)》
CAS
CSCD
北大核心
2009年第4期470-473,共4页
Journal of Xi’an Jiaotong University(Medical Sciences)
基金
陕西省科技计划资助项目(No .2006K09-G9)~~
关键词
乳腺癌
血管内皮生长因子C
MRNA
淋巴结转移
breast cancer
vascular endothelial growth factor C mRNA
lymph node metastasis