非小细胞肺癌气虚血瘀证患者血清血管内皮生长因子及内皮抑素的表达及意义

Significance and Expression of Vascular Endothelial Growth Factor and Endostatin in the Syndrome of Qi-Deficiency and Blood Stasis on Non-small Cell Lung Cancer

目的观察非小细胞肺癌气虚血瘀证患者外周血血清中血管内皮生长因子(vascularendothelial growth factor,VEGF)和内皮抑素(endostatin)的表达情况。方法用抽签法随机抽取ⅡB～Ⅲ期非小细胞肺癌患者82例,将入选患者严格按照中医气虚血瘀证诊断标准,分为气虚血瘀证组(41例)和非气虚血瘀证组(41例),采用酶联免疫法检测2组患者血清中VEGF和内皮抑素含量。结果气虚血瘀证组患者的血清VEGF和内皮抑素表达均高于非气虚血瘀证组患者,差异有统计学意义(P<0.01)。结论检测血清VEGF和内皮抑素可作为非小细胞肺癌气虚血瘀证的微观辨证依据;非小细胞肺癌气虚血瘀证患者较非气虚血瘀证患者可能存在更大的转移风险。

Objective To observe the serum levels of vascular endothelial growth factor（VEGF） and endostatin in patients with non-small cell lung cancer（NSCLC） ; offer the objective basis for estimating the patient＇s condition and prognosis. Methods Eighty-two patients with stage II B-Ⅲ non-small cell lung cancer were randomly selected and invided into two groups according to the diagnostic criteria of syndrome of qi-deficiency and blood stasis（SQDBS）. The serum level of VEGF and endostatin was detected by enzyme linked immunosorbent assay. Results Serum level of VEGF and endostatin was significantly higher in patient with the syndrome of SQDBS than in patient without the SQDBS; SQDBS was the key factor which had an effect upon these indexes. Conclusion Objective inner links are found between the SQDBS of NSCLC and VEGF, endostatin; the serum level of VEGF and endostatin can be served as the pathological basis of SQDBS in microcosmic ; non-small cell lung cancer patients with SQDBS may be at a greater risk of diversion than patients without SQDBS.