新辅助动脉介入化疗治疗高危型宫颈癌60例疗效分析

Effect of neoadjuvant chemotherapy on 60 patients with high risk type cervical carcinoma

目的探讨新辅助动脉介入化疗对高危型宫颈癌的疗效。方法入选60例患者,采用以铂类为基础的联合化疗方案,经子宫动脉介入给药,化疗结束后10～14d经评估后行广泛全子宫切除术+盆腔淋巴结清扫术,并观察分析患者病灶大小变化、毒副作用、手术情况等。结果60例宫颈癌患者的症状缓解率为100%;肿瘤直径<4cm者的有效率为84%;≥4cm者的有效率为63.6%,而且两个疗程优于一个疗程;副作用轻微。结论术前介入化疗及栓塞治疗可使肿瘤缩小,降低淋巴结转移率,提高手术切除率,是治疗宫颈癌的较佳模式。

Objective To investigate the effect of neoadjuvant chemotherapy （NACT） on 60 patients with high risk type cervical carcinoma. Methods Analyzed 60 cases with high risk type cervical carcinoma（stages Ⅰ b-- Ⅱb）, they were treated by cisplatin-- based chemotherapy for 1 -- 2 cycles followed by radical hysterectomy and lymphadenectomy. Drug side effect,the tumor size and involvement of surgical specimens were assessed during and after operation. Results 60 patients had completely clinical symptom release; the clinical response rate was 84 % in the group with small size（the maximum diameter （4cm） ,and 63.6% in other group（the minimum diameter≥4 cm）, furthermore 2 cycles chemotherapy was superior to 1 cycle. Conclusions Neoadjuvant chemotherapy can improve the clinical symptom and diminish the size of the tumor,which does the benefit for the radical operation.