重度子痫前期患者D-二聚体含量与妊娠结局的分析

Study on the relationship between d-dimer and pregnancy outcomes in patients with severe preeclampsia

目的探讨重度子痫前期患者D-二聚体升高对妊娠结局的影响。方法对98例住院分娩的重度子痫前期患者进行D-二聚体检测。按D-二聚体检测结果分为D-二聚体>246μg/L组及D-二聚体<246μg/L组,分别回顾围产儿结局及孕产妇并发症,分析D-二聚体升高与母儿结局的关系。结果重度子痫前期患者中D-二聚体异常升高者与D-二聚体检测正常者相比,FGR、新生儿低评分发生率明显升高,孕产妇并发症发生率也明显上升。结论重度子痫前期患者由于内皮细胞功能异常出现较早,导致凝血功能与纤溶抑制功能亢进,D-二聚体升高明显,测定D-二聚体含量,及时发现血管内皮细胞损伤,对于指导临床诊断和早期干涉治疗有一定的指导意义。

Objective To explore the relationship between d--dimer and pregnancy outcomes in patients with severe preeclampsia. Methods The blood samples were collected from 98 pregnancies with severe preeclampsia. D-- dimmer were measured, we divided the patients with severe preeclampsia into two groups：D--dimmer 〉246 ug/L and D--dimmer 〈246 ug/L,retrospective analysis of the maternal and perinatal outcomes,study on the relationship between d --dimer and the pregnancy outcomes. Results D--dimmer were obviously higher in pregnancies with severe preeclampsia, the incidence of FGR and low Apgar score were significantly higher in pregnancies whose D--dimmer 〉246 ug/L, and the preg- nancy complicating was higher too, （P 〈 0. 05）. Conclusions The damage of the endothelial occurred early in the patients with severe preeelampsia, the level of D--dimer was significantly higher, it leads to the disorders of coagulation and fibrinolysis. To examine the level of D--dimer is important for the diagnosis,prevention and therapy of pregnancy complicating with severe preeclampsia.