小剂量乙胺碘呋酮治疗快速性异位心律失常的远期疗效

Long-term effects of Low-dose Amiodarone in patients with achyarrhythmia

目的观察小剂量乙胺碘呋酮治疗快速性异位心律失常的远期疗效及安全性。方法将快速性异位心律失常患者80例随机分为两组:观察组小剂量维持治疗,乙胺碘呋酮剂量为每日20mg/kg,连用7日后,改为每日100mg,服用12个月。对照组大剂量负荷治疗,乙胺碘呋酮剂量为每日20mg/kg,连续服药6周,随访期间心律失常复发者重复以上治疗。观察用药后室性早搏数目和短阵室速发作时间,观察体表心电图12导联的Q-T间期及QT离散度变化;记录毒副作用的发生率。结果观察组有效率为88.6%,对照组有效率为22.2%,两组相比P<0.01;观察组治疗后ECG中Q-T间期为(480±38)ms,对照组为(540±28)ms,两组相比P<0.05;观察组毒副作用的发生率为13.5%,对照组为79.3%,两组相比P<0.05。结论小剂量乙胺碘呋酮维持疗法在快速性异位心律失常的治疗中高效、安全、副作用少,值得推广使用。

Objective To observe the long--term effects and safety of low--dose amiodarone in patients with achyarrhythmia. Methods 80 cases with achyarrhythmia were randomly divided into two groups： the treatment group （44 eases,amiodarone, 20 mg/kg×7 days, then, 100mg per day for 12 months）and the control group（36 cases, amiodarone, 20 mg/kg per day for 6 weeks, arrhythmia recur- rence repeat the above treatment）. The number of premature ventricular contractions,ventrieular taehycardia burst time and the QT interval of 12-lead surface ECG were observed, the incidence of side effects was recorded. Results In the treatment group, the effectiveness rate, the incidence of toxic and side effect and the QT interval were 88.6%, 13.3%, 480 ± 38ms, in the control group, were separately 22. 2%, 79.3% and 540±28ms, there was a significant difference between the two groups （P 〈 0.05or P 〈 0.01）. Conclusions The treatment of low--dose amiodarone in patients with achyarrhythmia was efficient, safe,less side effects, which is quite worthy of popularization.